LSP1 Summary

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LSP1 Details

Gene Symbol : LSP1

Gene Name : Lymphocyte-specific protein 1

Chromosome : CHR 11: 185,296,9-189,226,2

Locus : 11p15.5

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TSSC4 Summary

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

TSSC4 Details

Gene Symbol : TSSC4

Gene Name : Tumor suppressing subtransferable candidate 4

Chromosome : CHR 11: 240,040,8-240,387,7

Locus : 11p15.5

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