TUSC3 Summary

This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]

TUSC3 Details

Gene Symbol : TUSC3

Gene Name : Tumor suppressor candidate 3

Chromosome : CHR 8: 155,400,86-157,666,48

Locus : 8p22

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HOOK3 Summary

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

HOOK3 Details

Gene Symbol : HOOK3

Gene Name : Hook microtubule tethering protein 3

Chromosome : CHR 8: 428,968,89-430,305,38

Locus : 8p11.21

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