TMPRSS11D Summary

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

TMPRSS11D Details

Gene Symbol : TMPRSS11D

Gene Name : Transmembrane protease, serine 11D

Chromosome : CHR 4: 678,850,62-678,208,75

Locus : 4q13.2

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UBA6 Summary

Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]

UBA6 Details

Gene Symbol : UBA6

Gene Name : Ubiquitin like modifier activating enzyme 6

Chromosome : CHR 4: 677,011,70-676,157,60

Locus : 4q13.2

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