UBE4A Summary

This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

UBE4A Details

Gene Symbol : UBE4A

Gene Name : Ubiquitination factor E4A

Chromosome : CHR 11: 118,359,580-118,399,210

Locus : 11q23.3

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INSC Summary

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]

INSC Details

Gene Symbol : INSC

Gene Name : INSC, spindle orientation adaptor protein

Chromosome : CHR 11: 151,114,15-152,696,74

Locus : 11p15.2

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