MED20 Summary

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

MED20 Details

Gene Symbol : MED20

Gene Name : Mediator complex subunit 20

Chromosome : CHR 6: 419,211,46-419,053,52

Locus : 6p21.1

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UBR2 Summary

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

UBR2 Details

Gene Symbol : UBR2

Gene Name : Ubiquitin protein ligase E3 component n-recognin 2

Chromosome : CHR 6: 425,639,04-426,935,04

Locus : 6p21.1

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