ULK2 Summary

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

ULK2 Details

Gene Symbol : ULK2

Gene Name : Unc-51 like autophagy activating kinase 2

Chromosome : CHR 17: 198,679,25-197,708,27

Locus : 17p11.2

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DOCK6 Summary

This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]

DOCK6 Details

Gene Symbol : DOCK6

Gene Name : Dedicator of cytokinesis 6

Chromosome : CHR 19: 112,625,01-111,992,92

Locus : 19p13.2

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