UNC13B Summary

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]

UNC13B Details

Gene Symbol : UNC13B

Gene Name : Unc-13 homolog B

Chromosome : CHR 9: 351,619,73-354,053,36

Locus : 9p13.3

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TAF7L Summary

This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

TAF7L Details

Gene Symbol : TAF7L

Gene Name : TATA-box binding protein associated factor 7 like

Chromosome : CHR X: 101,293,070-101,268,252

Locus : Xq22.1

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