ADAP2 Summary

The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]

ADAP2 Details

Gene Symbol : ADAP2

Gene Name : ArfGAP with dual PH domains 2

Chromosome : CHR 17: 309,217,35-309,591,92

Locus : 17q11.2

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UNC5B Summary

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

UNC5B Details

Gene Symbol : UNC5B

Gene Name : Unc-5 netrin receptor B

Chromosome : CHR 10: 712,125,34-713,028,78

Locus : 10q22.1

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