| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UPF3A-CDC16-20-RERE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-REOR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-REGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-REGR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-REAQ | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-ORRE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-OROR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-ORGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-ORGR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-ORAQ | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GORE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GOOR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GOGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GOGR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GOAQ | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GRRE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GROR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GRGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GRGR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-GRAQ | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQRE | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQOR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQGO | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQGR | 20 (40 μL) | 200 μL |
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| UPF3A-CDC16-20-AQAQ | 20 (40 μL) | 200 μL |
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The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]
Gene Symbol : CDC16
Gene Name : Cell division cycle 16
Chromosome : CHR 13: 114,234,844-114,272,674
Locus : 13q34
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Gene Symbol : UPF3A
Gene Name : UPF3A, regulator of nonsense mediated mRNA decay
Chromosome : CHR 13: 114,281,583-114,305,816
Locus : 13q34
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