USP15 Summary

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

USP15 Details

Gene Symbol : USP15

Gene Name : Ubiquitin specific peptidase 15

Chromosome : CHR 12: 622,603,39-624,097,20

Locus : 12q14.1

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SRGAP1 Summary

The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]

SRGAP1 Details

Gene Symbol : SRGAP1

Gene Name : SLIT-ROBO Rho GTPase activating protein 1

Chromosome : CHR 12: 638,443,71-641,478,62

Locus : 12q14.2

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