USP35 Summary

This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]

USP35 Details

Gene Symbol : USP35

Gene Name : Ubiquitin specific peptidase 35

Chromosome : CHR 11: 781,888,11-782,336,50

Locus : 11q14.1

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TSHZ2 Summary

This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

TSHZ2 Details

Gene Symbol : TSHZ2

Gene Name : Teashirt zinc finger homeobox 2

Chromosome : CHR 20: 529,723,08-534,953,29

Locus : 20q13.2

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