USP4 Summary

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

USP4 Details

Gene Symbol : USP4

Gene Name : Ubiquitin specific peptidase 4

Chromosome : CHR 3: 493,401,02-492,771,43

Locus : 3p21.31

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SCRIB Summary

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SCRIB Details

Gene Symbol : SCRIB

Gene Name : Scribbled planar cell polarity protein

Chromosome : CHR 8: 143,815,378-143,790,919

Locus : 8q24.3

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