USP8 Summary

This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

USP8 Details

Gene Symbol : USP8

Gene Name : Ubiquitin specific peptidase 8

Chromosome : CHR 15: 504,243,58-505,010,82

Locus : 15q21.2

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BDP1 Summary

The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]

BDP1 Details

Gene Symbol : BDP1

Gene Name : B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB

Chromosome : CHR 5: 714,556,14-715,782,87

Locus : 5q13.2

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