USP9X Summary

This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

USP9X Details

Gene Symbol : USP9X

Gene Name : Ubiquitin specific peptidase 9, X-linked

Chromosome : CHR X: 410,854,19-412,365,78

Locus : Xp11.4

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MAPKAPK5 Summary

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

MAPKAPK5 Details

Gene Symbol : MAPKAPK5

Gene Name : Mitogen-activated protein kinase-activated protein kinase 5

Chromosome : CHR 12: 111,842,227-111,902,224

Locus : 12q24.12-q24.13

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