| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UTRN-HMGA2-20-RERE | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-REOR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-REGO | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-REGR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-REAQ | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-ORRE | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-OROR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-ORGO | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-ORGR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GORE | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GOOR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GOGO | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GOGR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GRRE | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GROR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GRGO | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GRGR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-AQRE | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-AQOR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-AQGO | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-AQGR | 20 (40 μL) | 200 μL |
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| UTRN-HMGA2-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Symbol : UTRN
Gene Name : Utrophin
Chromosome : CHR 6: 144,284,954-144,853,033
Locus : 6q24.2
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Symbol : HMGA2
Gene Name : High mobility group AT-hook 2
Chromosome : CHR 12: 658,244,59-659,662,90
Locus : 12q14.3
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