| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UVRAG-LRTOMT-20-RERE | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-REOR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-REGO | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-REGR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-REAQ | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-ORRE | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-OROR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-ORGO | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-ORGR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GORE | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GOOR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GOGO | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GOGR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GRRE | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GROR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GRGO | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GRGR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-AQRE | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-AQOR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-AQGO | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-AQGR | 20 (40 μL) | 200 μL |
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| UVRAG-LRTOMT-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Symbol : UVRAG
Gene Name : UV radiation resistance associated
Chromosome : CHR 11: 758,148,51-761,442,37
Locus : 11q13.5
This gene has evolved in primates as a fusion of two ancestral neighboring genes, Lrrc51 and Tomt, which exist as two independent genes in rodents. The fusion gene contains some shared exons, but encodes structurally unrelated proteins, LRTOMT1 and LRTOMT2. Those variants that utilize the more centromere-proximal 3' terminal exon (short transcript form) encode LRTOMT1, while those variants that use a more centromere-distal 3' terminal exon (long transcript form) encode the LRTOMT2 protein. There is a small region within one of the exons of this gene that contains overlapping alternate reading frames for both LRTOMT1 and LRTOMT2. LRTOMT1 shares similarity with the protein encoded by mouse Lrrc51, while LRTOMT2 shares similarity with the protein encoded by mouse Tomt. Alternative splicing results in multiple transcript variants, encoding different isoforms of both LRTOMT1 and LRTOMT2. The LRTOMT1 protein is a leucine-rich repeat-containing protein, while the LRTOMT2 protein is a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. [provided by RefSeq, Nov 2017]
Gene Symbol : LRTOMT
Gene Name : Leucine rich transmembrane and O-methyltransferase domain containing
Chromosome : CHR 11: 720,799,81-721,107,81
Locus : 11q13.4
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