VAV3 Summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

VAV3 Details

Gene Symbol : VAV3

Gene Name : Vav guanine nucleotide exchange factor 3

Chromosome : CHR 1: 107,964,922-107,571,159

Locus : 1p13.3

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ZHX2 Summary

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

ZHX2 Details

Gene Symbol : ZHX2

Gene Name : Zinc fingers and homeoboxes 2

Chromosome : CHR 8: 122,781,348-122,974,514

Locus : 8q24.13

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