| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| VHL-KIAA1430-20-RERE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-REOR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-REGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-REGR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-REAQ | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-ORRE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-OROR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-ORGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-ORGR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-ORAQ | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GORE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GOOR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GOGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GOGR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GOAQ | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GRRE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GROR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GRGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GRGR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-GRAQ | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQRE | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQOR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQGO | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQGR | 20 (40 μL) | 200 μL |
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| VHL-KIAA1430-20-AQAQ | 20 (40 μL) | 200 μL |
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Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Symbol : VHL
Gene Name : Von Hippel-Lindau tumor suppressor
Chromosome : CHR 3: 101,416,34-101,536,69
Locus : 3p25.3
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