TNFRSF8 Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TNFRSF8 Details

Gene Symbol : TNFRSF8

Gene Name : TNF receptor superfamily member 8

Chromosome : CHR 1: 120,633,17-121,442,12

Locus : 1p36.22

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VPS13D Summary

This gene encodes a protein belonging to the vacuolar-protein-sorting-13 gene family. In yeast, vacuolar-protein-sorting-13 proteins are involved in trafficking of membrane proteins between the trans-Golgi network and the prevacuolar compartment. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode distinct isoforms. [provided by RefSeq, Jul 2008]

VPS13D Details

Gene Symbol : VPS13D

Gene Name : Vacuolar protein sorting 13 homolog D

Chromosome : CHR 1: 122,300,38-125,120,46

Locus : 1p36.22-p36.21

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