VRK1 Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

VRK1 Details

Gene Symbol : VRK1

Gene Name : Vaccinia related kinase 1

Chromosome : CHR 14: 967,973,08-968,816,13

Locus : 14q32.2

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PAPOLA Summary

The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PAPOLA Details

Gene Symbol : PAPOLA

Gene Name : Poly(A) polymerase alpha

Chromosome : CHR 14: 965,023,75-965,671,15

Locus : 14q32.2

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