VRK2 Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

VRK2 Details

Gene Symbol : VRK2

Gene Name : Vaccinia related kinase 2

Chromosome : CHR 2: 579,076,50-581,639,90

Locus : 2p16.1

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CHSY1 Summary

This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011]

CHSY1 Details

Gene Symbol : CHSY1

Gene Name : Chondroitin sulfate synthase 1

Chromosome : CHR 15: 101,251,931-101,175,722

Locus : 15q26.3

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