PLAGL1 Summary

This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]

PLAGL1 Details

Gene Symbol : PLAGL1

Gene Name : PLAG1 like zinc finger 1

Chromosome : CHR 6: 144,064,598-143,940,299

Locus : 6q24.2

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WDFY3 Summary

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]

WDFY3 Details

Gene Symbol : WDFY3

Gene Name : WD repeat and FYVE domain containing 3

Chromosome : CHR 4: 849,663,90-846,695,36

Locus : 4q21.23

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