CHRNA3 Summary

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

CHRNA3 Details

Gene Symbol : CHRNA3

Gene Name : Cholinergic receptor nicotinic alpha 3 subunit

Chromosome : CHR 15: 786,212,94-785,930,51

Locus : 15q25.1

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WEE1 Summary

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]

WEE1 Details

Gene Symbol : WEE1

Gene Name : WEE1 G2 checkpoint kinase

Chromosome : CHR 11: 957,368,0-958,976,6

Locus : 11p15.4

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