WWP1 Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

WWP1 Details

Gene Symbol : WWP1

Gene Name : WW domain containing E3 ubiquitin protein ligase 1

Chromosome : CHR 8: 863,427,10-864,683,56

Locus : 8q21.3

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ESRP1 Summary

ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

ESRP1 Details

Gene Symbol : ESRP1

Gene Name : Epithelial splicing regulatory protein 1

Chromosome : CHR 8: 946,409,98-947,074,65

Locus : 8q22.1

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