NFAT5 Summary

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NFAT5 Details

Gene Symbol : NFAT5

Gene Name : Nuclear factor of activated T-cells 5

Chromosome : CHR 16: 695,659,51-697,046,65

Locus : 16q22.1

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WWP2 Summary

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

WWP2 Details

Gene Symbol : WWP2

Gene Name : WW domain containing E3 ubiquitin protein ligase 2

Chromosome : CHR 16: 697,622,83-699,417,40

Locus : 16q22.1

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