| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| XBP1-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-ORGR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| XBP1-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Gene Symbol : XBP1
Gene Name : X-box binding protein 1
Chromosome : CHR 22: 288,005,71-287,945,59
Locus : 22q12
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Symbol : CCT5
Gene Name : Chaperonin containing TCP1 subunit 5
Chromosome : CHR 5: 102,499,20-102,664,11
Locus : 5p15.2
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