XPO1 Summary

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

XPO1 Details

Gene Symbol : XPO1

Gene Name : Exportin 1

Chromosome : CHR 2: 615,385,21-614,779,33

Locus : 2p15

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HORMAD1 Summary

This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

HORMAD1 Details

Gene Symbol : HORMAD1

Gene Name : HORMA domain containing 1

Chromosome : CHR 1: 150,720,909-150,698,058

Locus : 1q21.3

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