SSRP1 Summary

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

SSRP1 Details

Gene Symbol : SSRP1

Gene Name : Structure specific recognition protein 1

Chromosome : CHR 11: 573,358,76-573,259,84

Locus : 11q12.1

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XPO4 Summary

XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]

XPO4 Details

Gene Symbol : XPO4

Gene Name : Exportin 4

Chromosome : CHR 13: 209,027,73-207,773,28

Locus : 13q12.11

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