XPR1 Summary

The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016]

XPR1 Details

Gene Symbol : XPR1

Gene Name : Xenotropic and polytropic retrovirus receptor 1

Chromosome : CHR 1: 180,632,009-180,890,278

Locus : 1q25.3

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ARHGEF11 Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ARHGEF11 Details

Gene Symbol : ARHGEF11

Gene Name : Rho guanine nucleotide exchange factor 11

Chromosome : CHR 1: 157,046,902-156,934,839

Locus : 1q23.1

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