DEDD Summary

This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

DEDD Details

Gene Symbol : DEDD

Gene Name : Death effector domain containing

Chromosome : CHR 1: 161,132,782-161,120,976

Locus : 1q23.3

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XPR1 Summary

The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016]

XPR1 Details

Gene Symbol : XPR1

Gene Name : Xenotropic and polytropic retrovirus receptor 1

Chromosome : CHR 1: 180,632,009-180,890,278

Locus : 1q25.3

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