NCF2 Summary

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

NCF2 Details

Gene Symbol : NCF2

Gene Name : Neutrophil cytosolic factor 2

Chromosome : CHR 1: 183,590,920-183,555,561

Locus : 1q25.3

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XPR1 Summary

The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016]

XPR1 Details

Gene Symbol : XPR1

Gene Name : Xenotropic and polytropic retrovirus receptor 1

Chromosome : CHR 1: 180,632,009-180,890,278

Locus : 1q25.3

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