XRN1 Summary

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

XRN1 Details

Gene Symbol : XRN1

Gene Name : 5'-3' exoribonuclease 1

Chromosome : CHR 3: 142,448,061-142,306,606

Locus : 3q23

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SMYD3 Summary

This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

SMYD3 Details

Gene Symbol : SMYD3

Gene Name : SET and MYND domain containing 3

Chromosome : CHR 1: 246,507,341-245,749,339

Locus : 1q44

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