YWHAE Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

YWHAE Details

Gene Symbol : YWHAE

Gene Name : Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

Chromosome : CHR 17: 140,037,4-134,448,9

Locus : 17p13.3

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INPP5K Summary

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

INPP5K Details

Gene Symbol : INPP5K

Gene Name : Inositol polyphosphate-5-phosphatase K

Chromosome : CHR 17: 151,688,7-149,457,4

Locus : 17p13.3

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