YWHAZ Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

YWHAZ Details

Gene Symbol : YWHAZ

Gene Name : Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

Chromosome : CHR 8: 100,954,067-100,918,575

Locus : 8q22.3

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GAL Summary

This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]

GAL Details

Gene Symbol : GAL

Gene Name : Galanin and GMAP prepropeptide

Chromosome : CHR 11: 686,844,74-686,911,74

Locus : 11q13.2

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