ZCCHC8-PTPN12 Fusion FISH Probe


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ZCCHC8-PTPN12-20-RERE 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-REOR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-REGO 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-REGR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-REAQ 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-ORRE 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-OROR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-ORGO 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-ORAQ 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GORE 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GOOR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GOGO 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GOAQ 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GROR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GRGR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-GRAQ 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-AQRE 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-AQOR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-AQGO 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-AQGR 20 (40 μL) 200 μL color color Request Pricing
ZCCHC8-PTPN12-20-AQAQ 20 (40 μL) 200 μL color color Request Pricing

PTPN12 Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

PTPN12 Details

Gene Symbol : PTPN12

Gene Name : Protein tyrosine phosphatase, non-receptor type 12

Chromosome : CHR 7: 775,371,59-776,400,70

Locus : 7q11.23


ZCCHC8 Summary

This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]

ZCCHC8 Details

Gene Symbol : ZCCHC8

Gene Name : Zinc finger CCHC-type containing 8

Chromosome : CHR 12: 122,501,072-122,471,598

Locus : 12q24.31


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