LIMA1 Summary

This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

LIMA1 Details

Gene Symbol : LIMA1

Gene Name : LIM domain and actin binding 1

Chromosome : CHR 12: 502,835,69-501,757,79

Locus : 12q13.12

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ZCRB1 Summary

Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

ZCRB1 Details

Gene Symbol : ZCRB1

Gene Name : Zinc finger CCHC-type and RNA binding motif containing 1

Chromosome : CHR 12: 423,261,29-423,120,85

Locus : 12q12

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