ZNF148-MYLK Fusion FISH Probe


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ZNF148-MYLK-20-RERE 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-REOR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-REGO 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-REGR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-REAQ 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-ORRE 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-OROR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-ORGO 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-ORAQ 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GORE 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GOOR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GOGO 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GOAQ 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GROR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GRGR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-GRAQ 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-AQRE 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-AQOR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-AQGO 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-AQGR 20 (40 μL) 200 μL color color Request Pricing
ZNF148-MYLK-20-AQAQ 20 (40 μL) 200 μL color color Request Pricing

MYLK Summary

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]

MYLK Details

Gene Symbol : MYLK

Gene Name : Myosin light chain kinase

Chromosome : CHR 3: 123,884,301-123,612,295

Locus : 3q21.1


ZNF148 Summary

The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]

ZNF148 Details

Gene Symbol : ZNF148

Gene Name : Zinc finger protein 148

Chromosome : CHR 3: 125,375,353-125,225,668

Locus : 3q21.2


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