ZNF292-MAP3K4 Fusion FISH Probe


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ZNF292-MAP3K4-20-RERE 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-REOR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-REGO 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-REGR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-REAQ 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-ORRE 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-OROR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-ORGO 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-ORAQ 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GORE 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GOOR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GOGO 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GOAQ 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GROR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GRGR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-GRAQ 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-AQRE 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-AQOR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-AQGO 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-AQGR 20 (40 μL) 200 μL color color Request Pricing
ZNF292-MAP3K4-20-AQAQ 20 (40 μL) 200 μL color color Request Pricing

MAP3K4 Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]

MAP3K4 Details

Gene Symbol : MAP3K4

Gene Name : Mitogen-activated protein kinase kinase kinase 4

Chromosome : CHR 6: 160,991,520-161,117,384

Locus : 6q26


ZNF292 Summary

This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]

ZNF292 Details

Gene Symbol : ZNF292

Gene Name : Zinc finger protein 292

Chromosome : CHR 6: 871,555,50-872,641,71

Locus : 6q14.3


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