| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ZNF341-CBFA2T2-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-ORGR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF341-CBFA2T2-20-AQAQ | 20 (40 μL) | 200 μL |
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In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Gene Symbol : CBFA2T2
Gene Name : CBFA2/RUNX1 translocation partner 2
Chromosome : CHR 20: 334,900,67-336,500,30
Locus : 20q11.21-q11.22
Gene Symbol : ZNF341
Gene Name : Zinc finger protein 341
Chromosome : CHR 20: 337,317,59-337,922,68
Locus : 20q11.22
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