This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ABL2-20-RE | 20 (40 μL) | 200 μL |  |
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| ABL2-20-OR | 20 (40 μL) | 200 μL |  |
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| ABL2-20-GO | 20 (40 μL) | 200 μL |  |
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| ABL2-20-GR | 20 (40 μL) | 200 μL |  |
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| ABL2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Gene Symbol : ABL2
Gene Name : ABL proto-oncogene 2, non-receptor tyrosine kinase
Chromosome : CHR 1: 179,229,692-179,099,326
Locus : 1q25.2
Alt. Genes : KIF20A
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