Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACIN1-20-RE | 20 (40 μL) | 200 μL |  |
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| ACIN1-20-OR | 20 (40 μL) | 200 μL |  |
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| ACIN1-20-GO | 20 (40 μL) | 200 μL |  |
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| ACIN1-20-GR | 20 (40 μL) | 200 μL |  |
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| ACIN1-20-AQ | 20 (40 μL) | 200 μL |  |
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Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Symbol : ACIN1
Gene Name : Apoptotic chromatin condensation inducer 1
Chromosome : CHR 14: 230,956,13-230,585,63
Locus : 14q11.2
Alt. Genes : G3BP1
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