The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACMSD-20-RE | 20 (40 μL) | 200 μL |  |
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| ACMSD-20-OR | 20 (40 μL) | 200 μL |  |
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| ACMSD-20-GO | 20 (40 μL) | 200 μL |  |
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| ACMSD-20-GR | 20 (40 μL) | 200 μL |  |
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| ACMSD-20-AQ | 20 (40 μL) | 200 μL |  |
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The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
Gene Symbol : ACMSD
Gene Name : Aminocarboxymuconate semialdehyde decarboxylase
Chromosome : CHR 2: 134,838,318-134,902,905
Locus : 2q21.3
Alt. Genes : SGK2
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