The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACSL5-20-RE | 20 (40 μL) | 200 μL |  |
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| ACSL5-20-OR | 20 (40 μL) | 200 μL |  |
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| ACSL5-20-GO | 20 (40 μL) | 200 μL |  |
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| ACSL5-20-GR | 20 (40 μL) | 200 μL |  |
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| ACSL5-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : ACSL5
Gene Name : Acyl-CoA synthetase long chain family member 5
Chromosome : CHR 10: 112,374,157-112,428,379
Locus : 10q25.2
Alt. Genes : DNAL4
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