This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ADAMTS12-20-RE | 20 (40 μL) | 200 μL |  |
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| ADAMTS12-20-OR | 20 (40 μL) | 200 μL |  |
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| ADAMTS12-20-GO | 20 (40 μL) | 200 μL |  |
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| ADAMTS12-20-GR | 20 (40 μL) | 200 μL |  |
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| ADAMTS12-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
Gene Symbol : ADAMTS12
Gene Name : ADAM metallopeptidase with thrombospondin type 1 motif 12
Chromosome : CHR 5: 338,921,79-335,235,34
Locus : 5p13.3-p13.2
Alt. Genes : OPTN
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