This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ADAMTS14-20-RE | 20 (40 μL) | 200 μL |  |
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| ADAMTS14-20-OR | 20 (40 μL) | 200 μL |  |
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| ADAMTS14-20-GO | 20 (40 μL) | 200 μL |  |
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| ADAMTS14-20-GR | 20 (40 μL) | 200 μL |  |
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| ADAMTS14-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
Gene Symbol : ADAMTS14
Gene Name : ADAM metallopeptidase with thrombospondin type 1 motif 14
Chromosome : CHR 10: 706,725,17-707,624,40
Locus : 10q22.1
Alt. Genes : OPTN
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