This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ADAMTS5-20-RE | 20 (40 μL) | 200 μL |  |
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| ADAMTS5-20-OR | 20 (40 μL) | 200 μL |  |
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| ADAMTS5-20-GO | 20 (40 μL) | 200 μL |  |
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| ADAMTS5-20-GR | 20 (40 μL) | 200 μL |  |
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| ADAMTS5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
Gene Symbol : ADAMTS5
Gene Name : ADAM metallopeptidase with thrombospondin type 1 motif 5
Chromosome : CHR 21: 269,671,19-269,179,11
Locus : 21q21.3
Alt. Genes : PREB
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