This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked cognitive disability. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AFF2-20-RE | 20 (40 μL) | 200 μL |  |
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| AFF2-20-OR | 20 (40 μL) | 200 μL |  |
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| AFF2-20-GO | 20 (40 μL) | 200 μL |  |
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| AFF2-20-GR | 20 (40 μL) | 200 μL |  |
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| AFF2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked cognitive disability. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2016]
Gene Symbol : AFF2
Gene Name : AF4/FMR2 family member 2
Chromosome : CHR X: 148,500,618-149,000,662
Locus : Xq28
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