This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AGRN-20-RE | 20 (40 μL) | 200 μL |  |
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| AGRN-20-OR | 20 (40 μL) | 200 μL |  |
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| AGRN-20-GO | 20 (40 μL) | 200 μL |  |
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| AGRN-20-GR | 20 (40 μL) | 200 μL |  |
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| AGRN-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Gene Symbol : AGRN
Gene Name : Agrin
Chromosome : CHR 1: 102,010,1-105,611,8
Locus : 1p36.33
Alt. Genes : ZNF263
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