This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AKR1C2-20-RE | 20 (40 μL) | 200 μL |  |
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| AKR1C2-20-OR | 20 (40 μL) | 200 μL |  |
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| AKR1C2-20-GO | 20 (40 μL) | 200 μL |  |
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| AKR1C2-20-GR | 20 (40 μL) | 200 μL |  |
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| AKR1C2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Symbol : AKR1C2
Gene Name : Aldo-keto reductase family 1 member C2
Chromosome : CHR 10: 501,803,2-498,777,4
Locus : 10p15.1
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