This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AKR1C4-20-RE | 20 (40 μL) | 200 μL |  |
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| AKR1C4-20-OR | 20 (40 μL) | 200 μL |  |
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| AKR1C4-20-GO | 20 (40 μL) | 200 μL |  |
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| AKR1C4-20-GR | 20 (40 μL) | 200 μL |  |
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| AKR1C4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
Gene Symbol : AKR1C4
Gene Name : Aldo-keto reductase family 1 member C4
Chromosome : CHR 10: 519,683,4-521,894,6
Locus : 10p15.1
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